Figure 4: Role of HDACs and HATs in CNS disorders. A defect in microtubule-based transport may contribute to the neuronal toxicity observed in Huntington's disease 144, and HDAC inhibition (for ...

LBH589 is a novel pan-histone deacetylase (HDAC) inhibitor that has potent antitumor activity in multiple myeloma and other hematological malignancies. However, its impact on the immune system has ...