Italfarmaco's oral HDAC inhibitor Duvyzat has been recommended for approval in the EU as a treatment for Duchenne muscular ...

It presents a structure–function analysis of four HDAC classes, the NAD +-independent and NAD +-dependent enzymes, subcellular localization, and substrates for deacetylation. Furthermore ...

Caption Using the PET scan tracer Martinostat, Mass. General Hospital investigators found that expression of HDAC epigenetic enzymes (red) is higher in a brain region (arrows) known to be ...

or are unable to selectively target certain HDAC enzymes of interest. One such underserved HDAC enzyme is HDAC6, which has been implicated to play crucial roles in cancer, neurodegenerative disease, ...

HDAC inhibitor LBH589 was provided by Novartis ... and subjected to the measurement of interferon (IFN)-γ production by enzyme-linked immunosorbent assay (ELISA). DCs following 6 days of culture ...