These include DNA methyltransferase and histone deacetylase (HDAC) inhibitors ... particular note is the enhancer of zeste homologue 2 (EZH2). Mutations and overexpression of EZH2 have been ...
LBH589 is a novel pan-histone deacetylase (HDAC) inhibitor that has potent antitumor activity in multiple myeloma and other hematological malignancies. However, its impact on the immune system has ...
The critical role of EZH2, an essential epigenetic regulator, in cancer progression and treatment is underscored in this new review article published in Genes & Diseases. The study highlights the ...
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