Given the tremendous therapeutic potential in cancer, it is likely that development of HDAC inhibitors, including entities to treat brain tumours, will continue for some time. However, after ...

Histone deacetylases (HDAC) remove acetyl groups from lysine residues making ... which aid in spreading the silencing signal. The genetic model of cancer – the idea that key mutations lead to ...

Propionate, while less studied as an HDAC inhibitor, showed similar chromatin ... potentially influencing cancer progression.

HDAC inhibitors and chemotherapy. Ultimately, the aim is to extend the time to relapse and prevent tumour resistance developing, in the hopes of effecting a functional cure for the cancer in more ...