Hepatitis B virus infection remains one of the leading causes of liver disease, including cirrhosis and hepatocellular carcinoma.

Researchers are now exploring strategies to silence cccDNA, aiming for a functional cure and offering hope to millions of patients worldwide. Hepatitis B virus infection remains one of the leading ...

and the opportunities currently under development to achieve the goal of HBV cure (bottom). cccDNA, covalently closed circular DNA; 3D, three-dimensional; DCs, dendritic cells; FNAs, fine-needle ...

It is notable that even in HBV patients who have achieved a functional cure, chronic HBV can be reactivated by suppressing the immune system 4. We hypothesize that reducing antigen levels to ...