Shanghai Helioson Pharmaceutical Co. Ltd. has synthesized molecular glue degraders comprising an E3 ubiquitin ligase coupled to a eukaryotic peptide chain release factor GTP-binding subunit ERF3A ...

The initial programs target CDK7/9, GSPT1, CK1a, IKAROS ... with transcriptional shutdown of leukemia oncogenes, including Myc and MCL1. Blocking CKIα, CDK7, and CDK9 augments and synergistically ...

In layperson’s terms, MRT-2359’s mechanism of action degrades the GSPT1 protein, which is a protein that certain cancers, such as CRPC, NSCLC, and SCLC, depend on to grow and survive.