In the time between growth hormone's arrival and IGF1 synthesis, there is a complex web of proteins that determines how much IGF1 is made. One such protein is SOCS2, which slows down IGF1 production.

According to the study by the Salk Institute, fasting promotes the secretion of growth hormone, which reduces BCL6 levels in muscle cells. BCL6 is a regulator of SOCS2, so less BCL6 leads to less ...