Eli Lilly's gene-silencing drug lepodisiran has been shown to reduce lipoprotein (a) levels by more than 90% for at least six ...

About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time. When X-linked genes evade silencing on the “inactive” ...

When cells divide and chromosomes are replicated for the daughter cells in a select type of cell called the germline, which is happening constantly in living things, sometimes things don’t go ...

These gene silencing proteins, referred to as Polycomb complexes, play critical roles in helping cells remember their own identity. While every type of cell in our body expresses a specific set of ...

This promiscuous binding activity means that miRNA can act on many different mRNAs, potentially silencing hundreds of genes simultaneously. In contrast, when RNAi is guided by siRNA, the entire ...

Scientists have shown that one portion of the petunia’s genetic code can direct the creation of molecules behind the plant’s floral scent. One of the approaches used was viral-induced gene silencing, ...

For decades, scientists thought that vertebrates had only one type of epigenetic modification on DNA called cytosine ...

Double-stranded RNA can be introduced experimentally to silence genes of interest. In plants, silencing can be triggered, for example, by engineering RNA viruses. In worms, silencing can be ...

Single IV administration of tau silencing gene therapy VY1706 significantly reduced tau mRNA and protein levels, with broad brain distribution ...

One potential strategy is to manipulate bacterial genes at the transcriptional level by silencing their resistance genes. However, siRNAs have not been applied to regulate bacterial genes due to ...

Manipulation of bacterial genes at the transcriptional level is a potential strategy to fight antibiotic-resistant bacterial infections by silencing their resistance genes. However, siRNAs have ...