Interestingly, CTLA-4 knockout mice and mice that lack expression of CTLA-4 just in T REG develop fatal, early-onset lymphoproliferative disease. 1,4 In addition, expression and signaling of CTLA ...

Oral presentation will feature AI-081, a potentially best-in-class PD-1/VEGF bispecific antibody and ONC-841, a ...

Agenus’s first-generation cytotoxic T lymphocyte protein 4 (CTLA-4) (AGEN1884) and programmed cell death 1 (PD-1) (AGEN2034) antagonists are in clinical studies as monotherapies and in ...

Immunotherapy drugs that block CTLA-4 are used to take the brakes off the ... and potentially we could make next-generation therapies that don't completely block IL-23 since it is still needed ...

Key Findings: In the proof of mechanism studies, CS2009 demonstrated strong synergy between the PD-1 and CTLA-4 arms, and the checkpoint inhibitory activity from the PD-1/CTLA4 arms was also ...