So-called GABA A receptors are proteins that control the flow of ions into and out of cells. As they play such a vital role in how neurons slow down or stop firing, they have become the targets of ...

The study, “The TMEM132B-GABAA receptor complex controls alcohol actions in the brain,” was authored by Guohao Wang, Shixiao Peng, Miriam Reyes Mendez, Angelo Keramidas, David Castellano ...

“We were unable to identify that individuals with autism had differences in GABAA receptor binding,” says Declan Murphy, a psychiatrist who studies brain development and neuropsychiatric disorders at ...

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One main class of these drugs, which includes propofol and the ether-derivative sevoflurane, work primarily by increasing the activity of inhibitory GABAA receptors, while a second class that includes ...

which got FDA approval last year for GABAA receptor PAM Zurzuvae (zuranolone) as a treatment for post-partum depression. Another rival is Karuna Therapeutics, acquired by Bristol-Myers Squibb for ...

As results indicated that the spinal antinociceptive effect of diazepam is mediated predominately by GABA A receptor isoforms containing the α2 and α3 subunits, the authors next tested whether ...

The phase 2a trial showed rapid onset as well as long-lasting pain reduction with Algiax's allosteric GABAA-receptor modulator AP-325, setting up further trials of the drug. Neuropathic pain can ...