Xiong has identified a key regulator for GTPase function called CalDAG-GEFI (CDGI) to control the switch of binding GTP or GDP of LRRK2 GTPase. Most other research has focused on understanding and ...

How does Ran GTPase control both protein import during interphase and spindle attachment to the chromosomes during M-phase? It all has to do with its concentration gradient in the cell.

Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activate ...

and that assembly of this wound actin cable is dependent on the small GTPase switch, Rho. We subsequently established the Drosophila embryo as a model to image the wound re-epithelialisation process ...

"Since these GTPases switch between 'on' and 'off' states ... openly in the hopes that others will use them to drug their GTPase of interest, whether it's a Rab GTPase, which is implicated ...

RanGDP is prevalent in the cytoplasm due to RanGAP and RanBPs to increase its GTPase activity. During import (left), importins bind to NLS-containing cargoes in the cytoplasm and translocate them ...