Revolution Medicines Inc. has disclosed macrocyclic compounds acting as GTPase KRAS (G12V mutant) inhibitors reported to be useful for the treatment of cancer.

Xiong published these findings in Science Advances. LRRK2 has two enzyme "domains"—a kinase and GTPase domain. Kinase is responsible for catalyzing the transfer of phosphate groups. GTPase binds ...

Scientists at Hyperway Pharmaceutical Co. Ltd. and Shenzhen Hyperway Pharmaceuticals Co. Ltd. have divulged GTPase KRAS (mutant) inhibitors reported to be useful for the treatment of cancer, LEOPARD ...

or a Rac GTPase, which plays a role in breast cancer. Among the hundreds of GTPases, there's rich potential to make progress for patients. "In the case of these enzymes, it was critical for us to ...

Thus, the GTPase activity of dynamin seems to have ... find in the search for small-molecule inhibitors of mechanochemical enzymes that will hopefully evolve into more specific as well as more ...

This shape change is driven by two enzymes: the small GTPase Rho and its activation enzyme GEF. By incorporating light-controllable molecular switches into GEF enzymes, the researchers managed to ...