In the case of GPCR signaling, the most suitable assay conditions depends on the GPCR coupling (Gq) efficacy as well as the pharmacological characteristics of the compound being studied (agonist or ...

Review the complexities of Gq-coupled GPCR signaling cascades with a highlight on second messengers. Read analysis of the drawbacks of Calcium Flux technology and learn how to minimize false positives ...

cAMP is a key mediator of GPCR signaling but is inversely regulated by Gαs and Gαi-coupled GPCRs, leading to assay challenges. Cisbio now offers cAMP HTRF assays optimized for your particular GPCR ...