This is mediated by the translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the cell surface. The insulin-responsive GLUT4 is retained intracellularly in ...

The glucose transporter GLUT4 facilitates insulin-stimulated glucose uptake into muscle and adipose tissue. Defects in glucose uptake represent an early step in the development of type 2 diabetes ...

We also determined whether elevated serum RBP4 levels are associated with reduced expression of glucose transporter 4 (GLUT4) in adipocytes, an early pathological feature of insulin resistance.

Of the top gene knockouts identified, the team found that knocking out Slc2a4—which encodes the insulin-dependent GLUT4 glucose transporter—notably improved the function of old NSCs.

The common forms of type 2 diabetes are caused by a constellation of genetic and epigenetic factors and molecular changes related to diet; lifestyle, including lack of exercise and sleep ...

Researchers at Daiichi Sankyo Co. Ltd. have developed a xanthene compound that can promote glucose uptake by GLUT4 into skeletal muscle.

The team identified 300 genes with the potential to stimulate these cells but focused on one in particular: the GLUT4 gene, which encodes a glucose transporter protein. Brunet and her colleagues ...