In this disorder, a mutation in the critical transcription factor gene forkhead box P3 (FOXP3) causes regulatory T cell dysfunction. The result is a collection of unwanted immune reactions appearing ...

Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function. Tregs play essential roles in immune homeostasis ...

“This study demonstrated that the inflammatory response in a subset of anal, penile, and vulvar HSILs was associated with PD-L1 and FOXP3 expression.” “This study demonstrated that the ...

Quell has developed a platform that works by ensuring the sustained expression of forkhead box P3 (FOXP3) in Treg cells. This protein is a crucial regulator of Treg cell gene expression and is ...

We are particularly interested in understanding the role of the forkhead family transcription factor Foxp3 in establishing and maintaining ... genetic approaches including conventional and conditional ...