The X chromosome–encoded forkhead domain containing transcription factor Foxp3 is a lineage-specifying factor responsible for the differentiation and function of T reg cells. This subtype of CD4 ...

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by a missense mutation in the FOXP3 forkhead domain. Panel A shows normal frequencies of FOXP3 ...

NOTE. Right-most column indicates characteristics of final patient cohort of 90 for which data derived from all three biomarkers (FOXP3, CD68, and CD20) were available, which was not significantly ...

Immune response too heavy? Autoimmune disease. From research in the past, scientists found that mutations in a gene called FOXP3 disrupted the Treg-coordinated immune balance. But now a study from the ...

Using a CRISPR screen, scientists at the Salk Institute have discovered a genetic “dial” to turn immune function up and down. The scientists suggest that the dial, which affects the ...

Correlation of high p95HER2:HER2 ratio with poor outcome in two phase II clinical trials of trastuzumab-treated HER2-positive metastatic breast cancer. This is an ASCO Meeting Abstract from the 2016 ...