Fibrinolytic therapy, also known as thrombolytic therapy, is used to lyse acute blood clots by activating plasminogen, resulting in the formation of plasmin, which cleaves the fibrin cross-links ...

The conversion of fibrinogen to fibrin, the final step in the blood coagulation sequence, is a complex but orderly reaction. Thrombin cleaves the long, axially oriented fibrinogen molecule at a ...