Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent ...

Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy ...

This graphical abstract shows how T-cells alter the metabolism of amino acids to cause ferroptosis. [University of Michigan Rogel Cancer Center] “Cancer immunotherapy restores or enhances the ...

Researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis. The hallmarks of cancer include rapid cell reproduction and metabolic ...

In a recent review published in the Cell Death Discovery Journal, researchers explored the association between ferroptosis and male reproductive failure, emphasizing the need for tailored ...

Patrizia Agostinis (VIB-KU Leuven) has found that melanoma cell populations protect themselves from a form of cell death called ferroptosis by secreting the lipoprotein apolipoprotein E (ApoE).

PRDX6 is a critical regulator of ferroptosis surveillance. As a selenium- acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein biosynthesis, including ...

This crucial advance in the fight against metastatic cancer is based on identifying the cellular site for ferroptosis initiation, a natural process, catalyzed by iron, that sparks the oxidative ...