Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity ...

These cells are consequently more sensitive to ferroptosis, a cell death process catalyzed by iron, which causes oxidation and the degradation of membrane lipids. Thanks to innovative chemistry ...

Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, researchers have discovered that lysosomal lipid peroxidation plays a ...

Researchers are still learning more about ferroptosis, a recently identified type of regulated cell death. It seems to be important to neuronal cell death after oxidative stress and is related to ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or programmed ...

Researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis. The hallmarks of cancer include rapid cell reproduction and metabolic ...

Different B cell subsets exhibit varying ferroptosis resistance, with B1a cells being highly susceptible. NK cells, key for tumor surveillance, are impaired by ferroptosis in tumor microenvironments.

They also showed that reconstitution of DHCR7 activity in these cells restored resistance to ferroptosis. Furthermore, they found that treatment with exogenous 7-DHC protected cells from ...

has found that melanoma cell populations protect themselves from a form of cell death called ferroptosis by secreting the lipoprotein apolipoprotein E (ApoE). Their work appears in Science Advances.