Febuxostat Open-label Clinical Trial of Urate-lowering Efficacy and Safety Adverse events were ... febuxostat 120-mg, and allopurinol groups, respectively. Serious adverse events were reported ...

Less than 50% reported following initial recommended dosages for allopurinol or febuxostat. Rheumatologists report largely adhering to American College of Rheumatology guidelines for gout ...

Febuxostat 40 mg daily appears to be as efficacious as allopurinol in lowering serum uric acid levels. [38] Both febuxostat 40 and 80 mg can be given to patients with mild-to-moderate renal impair ...