Transcription factors, especially FOXP1, are crucial in SCLC chemoresistance, influencing drug sensitivity and resistance pathways. FOXP1 regulates SP8 expression via its super-enhancer ...

Notably, the FoxP1 expression level itself is gated by Hox factors, as Dasen et al. 3 found that expression of the LMC Hox factors Hoxc6 or Hoxd10 in thoracic spinal motor neurons induced FoxP1 at ...