by down-regulating foxo1 gene expression and enhancing the degradation of FOXO1 protein through the phosphorylation of FOXO1. However, in innate lymphoid cells, these signaling pathways are not ...

Klebanoff wonders whether overexpressing FOXO1 in other T cell therapies might also give them a boost. In his own research, Klebanoff discovered that shutting down a molecular pathway driven by ...

Investigators also observed that this activation increased signaling in lymphedema-associated genes and caused the cells to export FOXO1, a protein known to repress lymphatic valve formation.

AKT regulates the cell cycle by phosphorylating FoxO1 and decreasing its transcription of CDK inhibitors p21 and p27. AKT, protein kinase B; CDK, cyclin dependent kinase; FoxO1, forkhead box O1 ...