Foxo1 is a transcription factor that regulates genes controlling many hepatic functions, including glucose production and lipid metabolism 5,7,8,9,10.Under physiological conditions insulin ...

image: FOXO1-mediated transcription regulates endothelial cells, influencing Tip cell formation and angiogenesis highlighting its pivotal role in vascular remodeling and EC function ...

FOXO1 levels rise in wounds of diabetic mice, but nobody had determined whether the high sugar levels in these animals alter the protein's function during healing.

Results suggest FOXO1 controls SOX2 and OCT4 expression. genprowebdirectory ... “The present study demonstrates an essential function for FOXO1 in the regulation of hESC fate,” the authors ...

Our study explores novel pathways for understanding FOXO1's functions in cellular processes, offering insights into vascular biology." Takashi Minami, Study Corresponding Author and Professor, ...

More information: Emilio Cosimo et al. AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival, Clinical Cancer Research (2018). DOI: 10.1158/1078 ...

When they reduced FOXO1 levels using CRISPR-Cas9 or blocked its activity with a small molecule inhibitor, it had the opposite effect: markers of memory function waned, and mice succumbed to the cancer ...

This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, June 1, 2012, in the JCI: "Improving obesity-induced insulin ...

Furthermore, deleting Foxo1 in a mouse model mimicking human lymphedema-distichiasis syndrome fully restored the both the number of valves and valve function. "It was exciting to see that Foxo1 is ...

"It was exciting to see that Foxo1 is the only gene so far reported that, when deleted, induces more lymphatic valves to form, instead of inhibiting valve growth," Dr. Yang said. "We actually ...

FOXO1 gene may play an important role in the pathological mechanisms of Parkinson's disease, say researchers. These findings are published online in PLoS Genetics, a peer-reviewed open-access ...