Furthermore, FOXO1 function is required for the robust activation of gluconeogenic gene expression in hepatic cells and in mouse liver by PGC-1α.

The data identify a heretofore unknown metabolic function of Notch and suggest that Notch inhibition is beneficial in diabetes treatment, in part by helping to offset excessive FoxO1-driven ...

FOXO1-mediated transcription regulates endothelial cells, influencing Tip cell formation and angiogenesis highlighting its pivotal role in vascular remodeling and EC function ...

We uncovered cell type-specific functions of FOXO1, shedding light on its role in VEGF-mediated Tip cell definition in primary cultured endothelial cells.

When they reduced FOXO1 levels using CRISPR-Cas9 or blocked its activity with a small molecule inhibitor, it had the opposite effect: markers of memory function waned, and mice succumbed to the cancer ...

The paper, "AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival," is published in Clinical Cancer Research.

FOXO1 levels rise in wounds of diabetic mice, but nobody had determined whether the high sugar levels in these animals alter the protein's function during healing.

To investigate a potential role for FOXO1 in hESC pluripotency, the team generated inducible FOXO1-specific knockdown systems based on two different short hairpin RNAs.

Furthermore, deleting Foxo1 in a mouse model mimicking human lymphedema-distichiasis syndrome fully restored the both the number of valves and valve function.

Using cancerous human lung tissue and a mouse model of EGFR-associated lung cancer, The Narla team discovered that two tumor suppressor genes, KLF6 and FOXO1, function to disrupt overactive EGFR ...

A University of South Florida preclinical study unexpectedly identified the gene Foxo1 as a potential treatment target for hereditary lymphedema.

New research shows that FOXO1 is required for memory in T cells and associated with more durable clinical responses to CAR T cell therapy.