"Our findings highlight the efficacy of AAV9-based gene therapy as a viable treatment strategy for FOXG1 syndrome and potentially other neurodevelopmental disorders with similar brain ...

The FOXG1 gene is especially important for generating and patterning the cerebral cortex, the part of the brain that is necessary for such functions as sensory perception and conscious thought.

[The results] eerily resembled some disorders that I had studied indirectly,” said Soo-Kyung Lee. Humans heterozygous for FOXG1 pathogenic variants, which typically arise from de novo mutations, ...

The study aimed at widening the clinical and genetic spectrum and assessing genotype–phenotype associations in FOXG1 syndrome due to FOXG1 variants. We compiled 30 new and 53 reported patients ...

Our 2-year-old son Eli’s diagnosis of a rare brain disorder called FOXG1 Syndrome upended our lives in every way imaginable. Without a cure, he is not expected to walk, talk or do anything ...

BUFFALO, N.Y. — University at Buffalo biologists Soo-Kyung and Jae Lee were already studying genetics and brain development when their daughter, Yuna, was born with a rare neurological disorder caused ...

Eli Reich has what's called FOXG1 Syndrome, a rare neurological condition. There are only about 700 documented cases worldwide. Scott Reich, Eli's dad, says the disorder causes cognitive impairment.

This mediated delivery of the FOXG1 gene via adeno-associated virus 9 (AAV9) is detailed in a study published June 5 in Molecular Therapy Methods & Clinical Development.A postnatal injection of ...

A viral gene therapy developed by UB researchers has reversed some brain abnormalities in infant mice with FOXG1 syndrome, a significant step toward one day treating children with this severe ...