The mutational spectrum of fibroblast growth factor receptor 3 (FGFR3) in individuals with achondroplasia. In humans, the mutations associated with achondroplasia patients are mainly located in ...

The activation of FGFR3–MAPK–STAT signaling pathway has been found to inhibit chondrocyte proliferation and extracellular matrix synthesis in the growth plate, leading to reduced endochondral ...

Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been shown to drive oncogenesis in a subset of patients with multiple myeloma. However, epithelial cancers — such as bladder ...

The article details how FGFR3 signaling suppresses critical pathways such as Indian hedgehog (IHH) and parathyroid hormone-related protein (PTHrP), and how its activation elevates cell cycle ...

The article details how FGFR3 signaling suppresses critical pathways such as Indian hedgehog (IHH) and parathyroid hormone-related protein (PTHrP), and how its activation elevates cell cycle ...