FGFR1-targeting Pemazyre was approved by the ... cause of cancer-related deaths for men in the country. FGFR2 gene fusion is observed in approximately 14% of intrahepatic cholangiocarcinoma ...

with FGFR1 rearrangement. In Japan, Pemazyre is approved for the treatment of patients with unresectable biliary tract cancer (BTC) with a FGFR2 fusion gene, worsening after cancer chemotherapy.