PPIs are among the highest-selling classes of ... according to IMS Health, which tracks drug sales and marketing. If you suffer from occasional heartburn and have not been diagnosed with GERD ...

PPIs are far more numerous than traditional drug discovery targets, so blocking PPIs potentially opens-up a much wider range of drug targets. PPIs have traditionally been considered too difficult ...

Millions of people take medications known as proton pump inhibitors (PPIs) to relieve heartburn, acid reflux, and related stomach issues.

SILVER SPRING, Md., March 28, 2025 /PRNewswire/ -- Today, the U.S. Food and Drug Administration approved Qfitlia (fitusiran) for routine prophylaxis to prevent or reduce the frequency of bleeding ...

In a secondary analysis, exposures to specific PPIs during the first trimester did not increase the risk for birth defects. Of note, omeprazole — the only category C drug (i.e., animal studies ...

A recent systematic review summarized the mostly 2-way comparative PPI trials that were published from 1988 through 2002 (Aliment Pharmacol Ther 2003; 18:559). Until one drug is shown to be ...