A new scientific review published in Neuropharmacology explores how the environment interacts with brain biology in shaping personality disorders. By examining molecular, neurochemical, and metabolic ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...

Next, researchers analyzed the mTOR signaling-related protein activation ... were associated with activation of the amygdala through ERK signaling. Further studies in a mouse model of depression ...

How relevant is this to patients? Using microarrays, the authors independently analysed PTEN–Akt–mTOR and Erk–MAPK signalling pathways in tissue samples from two cohorts of patients with ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...