Studies have found increased expression and activity of ERKs in cancer tissue, and an association with relapse after treatment. To clarify the role played by ERK proteins 1 and 2 (ERK1/2 ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

FGTI-2734 blocks cancer cells' wild type RAS membrane localization, prohibiting a cellular process called ERK reactivation, ...

Cancer patients invariably develop resistance to targeted drugs, so drugmakers develop strategies to combat it before ...

FGTI-2734 blocks cancer cells' wild type RAS membrane localization, prohibiting a cellular process called ERK reactivation, where ERK belongs to a family of enzymes that regulates communication ...

The laboratory is studying the role of Hsp90 family members in maintaining the transformed phenotype of cancer cells. Our recent work has shown that Hsp90 is critical for oncogenic RAF kinase-driven ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

Array Bridge is testing promising drug candidates that can effectively bind and even degrade target proteins, but not via ...

We need new approaches to treat this later stage of the disease.” Describing their results in Nature Microbiology (“ERK pathway reactivation prevents anthrax toxin lethality in mice”), Liu ...