In the study, published in Nature, they revealed the catalytic role of reactive oxygen species (ROS) superoxide (O 2 •-) in the heme-catalase-mediated synthesis of ergot alkaloids (EAs), a group ...

There are three classes of drugs for migraine: over-the-counter analgesics and nonsteroidal anti-inflammatory drugs for acute mild migraine, specific prescription drugs (triptans and ergot ...

Ergot alkaloids were the first antimigraine drugs available. Dihydroergotamine (DHE) is an ergotamine analog (Figure 3). DHE is administered as a nasal spray form (Migranal®, Valeant ...