Aims: To determine the maximum tolerated dose (MTD), safety and anti-tumor activity of afatinib combined with docetaxel in advanced cancer. Patients & methods: The MTD was determined from dose ...

The team was also able to reveal new details on MCL-1's function, identifying ways it suppresses another protein called BAK and how MCL-1 is regulated by a signaling pathway called ERBB.

EGF receptor (EGFR) and HER2 are two members of the ErbB/HER-family of tyrosine-kinase receptors that are frequently altered in breast cancer and several other malignancies, which inspired the ...