On ErbB1, ErbB3, (note inactive kinase, marked by a cross) or ErbB4 induces homodimer formation. Interestingly, when ErbB2 is overexpressed, heterodimers form preferentially. Unlike homodimers ...

six on ERBB2, and eleven on ERBB3 (Jones et al. 2006). ERBB4 also has phosphorylation sites, but they are less well characterized. Which ligand binds which receptor and what partner a receptor ...

Der Zelloberflächenrezeptor ERBB2 spielt eine zentrale Rolle in der Organentwicklung. Als Onkogen ist ERBB2 im überaktivierten Zustand jedoch auch an der Entstehung von Krebs, besonders Brustkrebs, ...