Furthermore, the addition of ligand for the ERBB2 dimerization partner, ERBB3, led to dissociation of HSP90 from ERBB2. These results suggested that HSP90 has a normal role in ERBB2 function ...

Each ERBB receptor has distinct locations and numbers of tyrosine phosphorylation sites on its C-terminal tails; there are twelve on ERBB1, six on ERBB2, and eleven on ERBB3 (Jones et al.

Multiple potential molecular markers for targeted therapy in USC are being studied. erbB2 is overexpressed in 20–50% of USC patients. erbB2 is more frequently overexpressed in African–American ...

Der Zelloberflächenrezeptor ERBB2 spielt eine zentrale Rolle in der Organentwicklung. Als Onkogen ist ERBB2 im überaktivierten Zustand jedoch auch an der Entstehung von Krebs, besonders Brustkrebs, ...