Interestingly, when ErbB2 is overexpressed, heterodimers form preferentially. Unlike homodimers, which are either inactive (ErbB3 homodimers) or signal only weakly, ErbB2-containing heterodimers ...

In 1994, P. Miller and colleagues looked at what would happen to cellular ERBB2 levels when cells were treated with herbimycin A (Miller et al. 1994). They used cells that normally express ERBB2 ...