Ephrin-B2 is required for the formation of blood and lymphatic vessels, but the mechanism has been enigmatic. Two independent studies show that ephrin-B2 controls the internalization and signaling ...

In the EphB/ephrin-B mutant animal, this cell-axon repulsive signal is lost, and instead most of these axons do not successfully project to the binocular pathway (lower image; the branch on the ...

The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are ...