During tissue development, how do migrating cells know where and when to stop? Eph-ephrin signaling is their cellular traffic light. Cell migration is a considerable challenge to the developing ...

Silencing of Ephs in malignancy or the expression of Eph RTK without ephrin binding and hence kinase activation may mean loss of forward signaling with resultant promotion of cell–matrix ...

In the EphB/ephrin-B mutant animal, this cell-axon repulsive signal is lost, and instead most of these axons do not successfully project to the binocular pathway (lower image; the branch on the ...

Science. (2014), May 29, pii: 1255149. [Epub ahead of print] Barton WA, Dalton AC, Seegar TC, Himanen JP, and Nikolov DB, Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling, Cold Spring ...

Expert Rev Hematol. 2012;5(3):325-340. Eph RTKs also differ from other RTKs in that they do not chiefly target nuclear transcription via their signaling cascades but rather target the cytoskeleton ...