A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency. The research is published in the journal Science Advances.

Kazantsev and colleagues, writing in Science, have shown that inhibitors of sirtuin 2 (SIRT2) — a member of the histone deacetylase family of enzymes — rescues α-synuclein-mediated toxicity ...

After a series of processes, they managed to isolate two enzymes considered key in this action that are SIRT2 and ALDH1A1. The first was detected at very high levels in both mice and humans after ...