E-cadherin is a transmembrane glycoprotein involved in epithelial cell adhesion. In cancer, downregulation of this protein enhances tumor cell dissociation, thereby increasing the risk of ...

One of the major constituents of the cell-adhesion complex in epithelial cells is E-cadherin, a transmembrane protein involved in homotypic cell–cell adhesion. E-cadherin exerts a potent ...

Additionally, the investigators found that these "pre-junctions" form through polymerization of the E-cadherin interacting protein called alpha-catenin along the cytoskeleton filaments.