“Our findings suggest a role for NSD2 in maintaining MM cell identity, with potential implications for future therapeutic strategies based on targeting of NSD2.” “Our findings suggest a role ...

Both drugs target EZH2, a protein that helps control which genes are active or silent. After just 48 hours of drug exposure, the cells began producing insulin and responding to glucose—just like ...

NSD2 catalyzes the mono- and di-methylation of the e-amine of lysine 36 from histone H3, utilizing the methyl donor S-adenosyl-L-methionine. Increased catalytic activity of NSD2, either by ...

A new research paper was published in Oncotarget, Volume 16, on March 21, 2025, titled "NSD2-epigenomic reprogramming and maintenance of plasma cell phenotype in t(4;14) myeloma." Researchers ...

Histone methylation (H3K36me3 barrier) by NSD2 promotes the functions of genes involved in cell proliferation. NSD2 decreases in senescent cells, which causes altered epigenome and gene expression ...