Furthermore, the investigators found that EZH2-mediated methylation regulates PARP1 transcriptional and oncogenic activity in part by impairing an interaction between PARP1 and the E2F1 gene ...
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
The critical role of EZH2, an essential epigenetic regulator, in cancer progression and treatment is underscored in this new review article published in Genes & Diseases. The study highlights the ...
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