ESR1 gene mutations are known to be linked to hormone receptor-positive (HR+) metastatic breast cancer. The research-use-only assay, which includes a qPCR detection kit and an isolation kit for ...

HER2-negative advanced breast cancer whose tumours express ESR1 gene mutations that are linked to resistance to hormonal therapies. The study compared camizestrant in combination with CDK4/6 ...

although that trial is also targeting tumours that express ESR1 gene mutations. Among other drugs in the class, Sanofi's amcenestrant – which was in the lead among the oral SERD class at one ...

Estrogen functions through binding of two different estrogen receptors (ESRs), ESR1 and ESR2. Estrogen plays an important role in bone biology, best illustrated by three points of observations ...