This study has revealed how the ZIC2 gene, in collaboration with the ARID1A-BAF complex, plays a crucial role in a process known as epithelial-to-mesenchymal transition (EMT). This process enables ...

Background Muscle wasting and weakness (sarcopenia) are commonly associated with COPD causing frailty and reduced quality of ...

Down-regulation of ELOVL2 promotes EMT in breast cancer by up-regulating expression of SREBP1/2. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and ...

Our work provided a conceptual understanding depicting a causal role for RNA alternative splicing in EMT and breast cancer recurrence. We found that splice isoform switching of the CD44 gene must take ...