The E6 viral oncoprotein binds to p53, resulting in ubiquitination of the cellular protein, targeting p53 for proteosome-mediated degradation. p53 normally functions to gauge DNA damage ...

In this article we give an overview of RNA-based HPV diagnostics and the role of E6/E7 mRNA detection as a predictive marker for the development of cervical carcinoma. HPV E6/E7 mRNA testing for ...