Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs ... of RB activity is the inhibition of E2F activity, which is important for the transcription of ...

E2F activity is repressed in normal noncancerous cells by the tumor suppressor retinoblastoma protein (Rb). The Rb pathway is one of the most important tumor suppressor pathways commonly defective ...