E2F activity is repressed in normal noncancerous cells by the tumor suppressor retinoblastoma protein (Rb). The Rb pathway is one of the most important tumor suppressor pathways commonly defective ...

One downstream consequence of RB activity is the inhibition of E2F activity, which is important for the transcription of several genes that are required for progression through the G1 and S phases ...

Press Release Circle Pharma, a clinical-stage biopharmaceutical company focused on developing cell-permeable macrocycle therapeutics, today announced a late-breaking poster presentation at the ...