After UV-induced RNA damage, the proteins DHX9 (green) and G3BP1 (red) form stress granules in the cytoplasm. The cell nuclei are displayed in blue colour. DHX9 is also found in the nucleus.

After UV-induced RNA damage, the DHX9 (yellow) and G3BP1 (purple) proteins form stress granules after cell division. Live cell imaging of HeLa cells.

ATX-559, a first-in-class oral DHX9 inhibitor, shown to induce potent and selective tumor growth inhibition in preclinical models of cancers with high genomic instability and replication stress ...

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in understanding cancer ...

RBPs play a crucial role in circRNA biogenesis and function, with specific proteins like QKI, SP1, FUS, ADAR1, and DHX9 shown ...