As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations. These ...

A new study reveals how the Dnmt3a mutation drives blood stem cell overgrowth, contributing to clonal hematopoiesis and ...

People at high risk of acute myeloid leukaemia (AML) can be identified years in advance, but there is currently no treatment ...

Metformin, which is mainly used to control diabetes, could help prevent an aggressive form of blood cancer, a new study ...

A widely used diabetes drug holds promise in the treatment of the third biggest cancer killer in the UK, new research ...

Led by Jennifer Trowbridge, professor and The Dattels Family Chair at JAX, the study reported today in the April 16 issue of Nature Communications reveals that a common aging-associated mutation in ...

Both groups possessed some blood cells with changes to a gene associated with leukemia. But the changes to that gene called DNMT3A were not in the areas associated with preleukemia. To see if this ...

Mutations in DNMT3A, a gene commonly altered in leukemia, were observed in both donor groups. However, the mutations present in frequent donors were in regions of the gene not previously associated ...

For example, both sample groups contained clones with changes to a gene called DNMT3A, which is known to be mutated in people who develop leukaemia. Interestingly, the changes to this gene ...

In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and ...