This result indicates a specific and definitive role for Dnm1 in the fission process and that this protein does not function simply as a negative regulator of fusion. The specific molecular role ...

Three central players are (1) mitofusins (outer mitochondrial membrane fusion), (2) OPA1/Mgm1 (inner mitochondrial membrane fusion), and (3) Drp1/Dnm1 (division of outer and inner mitochondrial ...