To test their hypothesis, the researchers developed a new and very sensitive DNA sequencing technology that could discern genuine errors made by Pol ε during DNA replication from experimental ...

For example, researchers know that RNA pol II can bind to a DNA sequence within the promoter of many genes, known as the TATA box, to initiate transcription. Together with other common motifs ...

He added: "While our lead DNA pol IIIC inhibitor is Phase 3-ready for oral treatment of C. difficile Infection, our second generation compounds in our program are systemically absorbed for ...

If DNA is a book, then how is it read? Learn more about the DNA transcription process, where DNA is converted to RNA, a more portable set of instructions for the cell. The process of transcription ...

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

The Company's approach is to develop antibiotic candidates with a Gram-positive selective spectrum (GPSS®) that blocks the active site of the Gram-positive specific bacterial enzyme DNA ...