To understand how this looping eventually gives rise to rod-shaped chromosomes, the researchers built a computational model based on two simple assumptions. First, as observed, DNA forms ...

However, observing how this looping process occurs on the cellular scale and contributes to chromosome structure is challenging. This is because methods for visualising DNA with high resolution ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

Enhancers can be thousands of nucleotides away from the promoters with which they interact, but they are brought into proximity by the looping of DNA. This looping is the result of interactions ...

These loops of DNA are generated in the cell by a set of ... According to Dr. Gibcus, during the mitotic phase of cell division, four different loop-extruding machines are acting simultaneously ...

A schematic showing how R-loops, a hybrid of RNA and DNA, can form during DNA transcription when the messenger RNA chain being assembled by the RNA polymerase binds to one of the DNA strands.

The relatively large bacterial DNA can then be separated from the smaller DNA loop that makes up the vector. Fill the syringe with the altered vectors. Upon inoculation, billions of copies of the ...

“That was really where it became intriguing that we could artificially create something that could create a DNA loop that was as strong as that could be seen in the lac repressor system,” Becker said.